Histologic finding of pancreatic islet tissue following intraportal human islet allotransplantation.
نویسندگان
چکیده
THE ultimate test of viability of separated human islets is functional activity after transplantation into a diabetic recipient. Morphologic identification of insulin-containing transplanted islets could provide important correlative data and eventually confirm the functional results. The present report describes identification of intrahepatic islet tissue following human islet allotransplantation.
منابع مشابه
Detection of pancreatic islet tissue following islet allotransplantation in man.
Qualitative and quantitative standards have been recently proposed for islet isolation asaeument in humans and large animals ( 1). The ultimate test of viability is functional activity after transplantation into a diabetic recipient. Morphologic identification of insulin-containing transplanted islets could provide important correlative data and eventually confmn the functional results. Recentl...
متن کاملOutcome of human islet isolation and allotransplantation in 20 consecutive cases.
This report provides our initial experience on islet isolation and intrahepatic allotransplantation in 20 patients. In Group 1, 10 patients underwent combined liver-islet allotransplantation following upper-abdominal exenteration for cancer. One patient underwent pancreatic islet allograft after near total pancreatectomy for chronic pancreatitis. In Group 2, 3 Type I diabetic patients received ...
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Refined methods of islet cell purification have led to unprecedented success of islet cell allotransplantation via portal vein infusion in diabetic patients, resulting in marked reduction of exogenous insulin requirements and recently even insulin independence. The authors report the histologic findings of islet cell allografts in the liver of four patients who had undergone combined kidney-isl...
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THE most successful outcome of pancreatic islet allotransplantation has been in patients with upper abdominal malignancies who have undergone cluster resection followed by liver replacement. I.2 Between January 1990 and June 1992. 11 patients underwent this procedure; six (55%) of whom were insulin-independent until demise, due to recurrence of the primary disease. We report herein. a 58-month ...
متن کاملSuccessful treatment of brittle diabetes following total pancreatectomy by islet allotransplantation: a case report.
CONTEXT Allotransplantation of islets can successfully treat subjects with type 1 diabetes complicated by severe hypoglycemia and erratic glycemic control. Insulin independence is often lost over time due to several factors, including recurrent autoimmunity. Brittle diabetes (frequent hypoglycemia and labile glycemic control) is common after pancreatectomy. This is ameliorated by auto-islet tra...
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ورودعنوان ژورنال:
- Transplantation proceedings
دوره 24 3 شماره
صفحات -
تاریخ انتشار 1992